• ADHD symptoms and diagnosis in adult preterms: systematic review, IPD meta-analysis, and register-linkage study 

      Robinson, Rachel; Girchenko, Polina; Pulakka, Anna; Heinonen, Kati; Lähdepuro, Anna; Lahti-Pulkkinen, Marius; Hovi, Petteri; Tikanmäki, Marjaana; Bartmann, Peter; Lano, Aulikki; Doyle, Lex W.; Anderson, Peter J.; Cheong, Jeanie L. Y.; Darlow, Brian A.; Woodward, Lianne J.; Horwood, L. John; Indredavik, Marit Sæbø; Evensen, Kari Anne Indredavik; Marlow, Neil; Johnson, Samantha; de Mendonca, Marina Goulart; Kajantie, Eero Olavi; Wolke, Dieter; Räikkönen, Katri (Peer reviewed; Journal article, 2022)
      Background This study examined differences in ADHD symptoms and diagnosis between preterm and term-born adults (≥18 years), and tested if ADHD is related to gestational age, birth weight, multiple births, or neonatal ...
    • Characteristics of epigenetic aging across gestational and perinatal tissues 

      Dieckmann, Linda; Lahti-Pulkkinen, Marius; Kvist, Tuomas; Lahti, Jari; DeWitt, Peter E.; Cruceanu, Cristiana; Laivuori, Hannele; Sammallahti, Sara; Villa, Pia M.; Suomalainen-König, Sanna; Eriksson, Johan G.; Kajantie, Eero Olavi; Raikkönen, Katri; Binder, Elisabeth B.; Czamara, Darina (Peer reviewed; Journal article, 2021)
      Background: Epigenetic clocks have been used to indicate differences in biological states between individuals of same chronological age. However, so far, only few studies have examined epigenetic aging in newborns—especially ...
    • Effect of Vitamin D3 Supplementation in the First 2 Years of Life on Psychiatric Symptoms at Ages 6 to 8 Years: A Randomized Clinical Trial 

      Sandboge, Samuel; Räikkönen, Katri; Lahti-Pulkkinen, Marius; Hauta-Alus, Helena; Holmlund-Suila, Elisa; Girchenko, Polina; Kajantie, Eero Olavi; Mäkitie, Outi; Andersson, Sture; Heinonen, Kati (Peer reviewed; Journal article, 2023)
      Importance Vitamin D is associated with neurodevelopment, but causality, critical windows, and potentials for modification remain unknown. Objective To determine the impact of high-dose (1200 IU) vs standard-dose (400 ...
    • Genome-Wide Copy Number Variant and High-Throughput Transcriptomics Analyses of Placental Tissues Underscore Persisting Child Susceptibility in At-Risk Pregnancies Cleared in Standard Genetic Testing 

      Czamara, Darina; Cruceanu, Cristiana; Lahti-Pulkkinen, Marius; Dieckmann, Linda; Ködel, Maik; Sauer, Susann; Rex-Haffner, Monika; Sammallahti, Sara; Kajantie, Eero Olavi; Laivuori, Hannele; Lahti, Jari; Räikkönen, Katri; Binder, Elisabeth B. (Peer reviewed; Journal article, 2022)
      Several studies have shown that children from pregnancies with estimated first-trimester risk based on fetal nuchal translucency thickness and abnormal maternal serum pregnancy protein and hormone levels maintain a higher ...
    • Maternal exposure to childhood maltreatment and mental and behavioral disorders in children 

      Airikka, Aino; Lahti-Pulkkinen, Marius; Tuovinen, Soile; Heinonen, Kati; Lahti, Jari; Girchenko, Polina; Lähdepuro, Anna; Pyhälä, Riikka; Czamara, Darina; Villa, Pia; Laivuori, Hannele; Kajantie, Eero Olavi; Binder, Elisabeth B.; Räikkönen, Katri (Peer reviewed; Journal article, 2022)
      Exposure to maltreatment in childhood is associated with lifelong risk of mental and behavioral disorders. Whether the effects extend to the next generation remains unclear. We examined whether maternal exposure to childhood ...
    • Optimism in adults born preterm: Systematic review and individual-participant-data metaanalysis 

      Robinson, Rachel K.; Heinonen, Kati; Girchenko, Polina; Lahti-Pulkkinen, Marius; Kajantie, Eero Olavi; Hovi, Petteri; Lano, Aulikki; Andersson, Sture; Eriksson, Johan G.; Wolke, Dieter; Lemola, Sakari; Raikkonen, Katri (Peer reviewed; Journal article, 2021)
      Aim Preterm birth(<37 gestational weeks) is associated with numerous adversities, however, data on positive developmental outcomes remain limited. We examined if preterm and term born(≥37 gestational weeks) adults differ ...
    • A polyepigenetic glucocorticoid exposure score at birth and childhood mental and behavioral disorders 

      Suarez, Anna; Lahti, Jari; Lahti-Pulkkinen, Marius; Girchenko, Polina; Czamara, Darina; Arloth, Janine; Malmberg, Anni LK.; Hämäläinen, Esa; Kajantie, Eero Olavi; Laivuori, Hannele; Villa, Pia M.; Reynolds, Rebecca M.; Provençal, Nadine; Binder, Elisabeth B.; Räikkönen, Katri (Peer reviewed; Journal article, 2020)
      Background Maternal depression and anxiety during pregnancy may enhance fetal exposure to glucocorticoids (GCs) and harm neurodevelopment. We tested whether a novel cross-tissue polyepigenetic biomarker indicative of in ...
    • Positive maternal mental health during pregnancy and mental and behavioral disorders in children: A prospective pregnancy cohort study 

      Lähdepuro, Anna; Lahti-Pulkkinen, Marius; Pyhälä, Riikka; Tuovinen, Soile; Lahti, Jari; Heinonen, Kati; Laivuori, Hannele; Villa, Pia M.; Reynolds, Rebecca M.; Kajantie, Eero Olavi; Girchenko, Polina; Räikkönen, Katri (Journal article; Peer reviewed, 2022)
    • Reliability of a novel approach for reference-based cell type estimation in human placental DNA methylation studies 

      Dieckmann, Linda; Cruceanu, Cristiana; Lahti-Pulkkinen, Marius; Lahti, Jari; Kvist, Tuomas; Laivuori, Hannele; Sammallahti, Sara; Villa, Pia M.; Suomalainen-König, Sanna; Rancourt, Rebecca C.; Plagemann, Andreas; Henrich, Wolfgang; Eriksson, Johan G.; Kajantie, Eero Olavi; Entringer, Sonja; Braun, Thorsten; Räikkönen, Katri; Binder, Elisabeth B.; Czamara, Darina (Peer reviewed; Journal article, 2022)
      The placenta is a central organ during early development, influencing trajectories of health and disease. DNA methylation (DNAm) studies of human placenta improve our understanding of how its function relates to disease ...